Gossypol
نویسندگان
چکیده
منابع مشابه
Biosynthesis of Gossypol
Based on the previous observations that gossypol is biosynthetically formed from acetate, and from the location of the incorporated 1% atoms, gossypol biosynthesis via the isoprenoid pathway has been postulated. To support this hypothesis, the incorporation of mevalonate-2J4C (a key intermediate in the isoprenoid pathway) into gossypol as well as the distribution of the radioactivity in the gos...
متن کاملGossypol Toxicity from Cottonseed Products
Gossypol is a phenolic compound produced by pigment glands in cotton stems, leaves, seeds, and flower buds (Gossypium spp.). Cottonseed meal is a by-product of cotton that is used for animal feeding because it is rich in oil and proteins. However, gossypol toxicity limits cottonseed use in animal feed. High concentrations of free gossypol may be responsible for acute clinical signs of gossypol ...
متن کاملGossypol inhibition of adenylate cyclase.
Gossypol, a polyphenolic binaphthalene -dialdehyde reputed to exert contraceptive action in males, reversibly inhibits adenylate cyclase [ATP pyrophosphate lyase (cyclizing), EC 4.6.1.1] in a concentration-dependent manner. In membranes prepared from a variety of organs, the half-maximal inhibitory concentration (IC50) ranges from 75 microM (rat Leydig tumor cells) to 250 microM (rat liver memb...
متن کاملGossypol, the Toxic Substance in Cottonseed
Since our previous publication (17) on this subject, several articles have appeared in which other explanations of cottonseed-meal poisoning have been offered. Thus, Rommel and Vedder (14) have suggested that poisoning by cottonseed meal is similar to beriberi, and is caused by deficient diets. This view was based on the similarity of post-mortem symptoms noted in pigs fed on rice and tankage. ...
متن کاملProteinaceous diet inhibits gossypol-induced spermatotoxicity.
The present study was designed to investigate the effect of a proteinaceous dietary supplement, fishmeal, on gossypol-induced spermatotoxicity. Twenty-five adult male Wistar rats, averaging 205 g b.w., were randomly sorted into four experimental groups (I-IV) of 5 animals each, and a control group. Crude cottonseed oil was administered orally to each animal in groups I-IV at a rate that provide...
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ژورنال
عنوان ژورنال: International Journal of Andrology
سال: 1982
ISSN: 0105-6263,1365-2605
DOI: 10.1111/j.1365-2605.1982.tb00304.x